Transducin: Difference between revisions
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 32: | Line 32: | ||
**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br /> | **[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br /> | ||
**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br /> | **[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br /> | ||
**[[5he0]], [[5he1]], [[5he2]], [[5he3]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br /> | **[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br /> | ||
**[[4pnk]] – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br /> | **[[4pnk]] – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br /> | ||
**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br /> | **[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br /> | ||
| Line 48: | Line 48: | ||
**[[3sn6]] – TDN bα (mutant) + rβ (mutant) +bγ + endolysine + antibody fragment<br /> | **[[3sn6]] – TDN bα (mutant) + rβ (mutant) +bγ + endolysine + antibody fragment<br /> | ||
**[[5tdh]] – TDN hα (mutant) + rβ + bγ + GDP<br /> | **[[5tdh]] – TDN hα (mutant) + rβ + bγ + GDP<br /> | ||
**[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br /> | |||
**[[5vai]] – TDN hα + rβ + bγ+ glucagon-like peptide + antibody fragment - Cryo EM<br /> | |||
}} | }} | ||
== References == | == References == | ||
Revision as of 20:26, 11 October 2017
FunctionTransducin (TDN) or Heterotrimeric G protein or Guanine nucleotide-binding protein G is a which are organized in two subunits: α and βγ[1]. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit. DiseaseCongenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit[2].
|
| ||||||||||
3D structures of transducin3D structures of transducin
Updated on 11-October-2017
ReferencesReferences
- ↑ Lerea CL, Bunt-Milam AH, Hurley JB. Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina. Neuron. 1989 Sep;3(3):367-76. PMID:2534964
- ↑ Dryja TP, Hahn LB, Reboul T, Arnaud B. Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness. Nat Genet. 1996 Jul;13(3):358-60. PMID:8673138 doi:http://dx.doi.org/10.1038/ng0796-358