5q0r: Difference between revisions

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-'''Unreleased structure'''
-The entry 5q0r is ON HOLD
+==Ligand binding to FARNESOID-X-RECEPTOR==
+<StructureSection load='5q0r' size='340' side='right' caption='[[5q0r]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
-Authors: Benz, J., Burger, D., Joseph, C., Rudolph, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5q0r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Q0R FirstGlance]. <br>
-Description: Ligand binding to FARNESOID-X-RECEPTOR
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9LG:N,1-dibenzyl-6-[(2-fluorophenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide'>9LG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5q0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q0r OCA], [http://pdbe.org/5q0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5q0r RCSB], [http://www.ebi.ac.uk/pdbsum/5q0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5q0r ProSAT]</span></td></tr>
-[[Category: Joseph, C]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Benz, J]]
-[[Category: Rudolph, M]]
 [[Category: Burger, D]]
+[[Category: Burley, S K]]
+[[Category: Joseph, C]]
+[[Category: Kuhn, B]]
+[[Category: Rudolph, M G]]
+[[Category: Ruf, A]]
+[[Category: Shao, C]]
+[[Category: Thoma, R]]
+[[Category: Yang, H]]
+[[Category: D3r]]
+[[Category: Docking]]
+[[Category: Fxr]]
+[[Category: Transcription]]