5gmi: Difference between revisions

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'''Unreleased structure'''


The entry 5gmi is ON HOLD  until Paper Publication
==Crystal Structure of GRASP55 GRASP domain in complex with JAM-C C-terminus==
 
<StructureSection load='5gmi' size='340' side='right' caption='[[5gmi]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
Authors: Shi, N., Shi, X., Morelli, X., Betzi, S., Huang, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5gmi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GMI FirstGlance]. <br>
Description: Crystal structure of Grasp domain of Grasp55 complexed with the Peptide
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gmj|5gmj]], [[5gml|5gml]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gmi OCA], [http://pdbe.org/5gmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gmi RCSB], [http://www.ebi.ac.uk/pdbsum/5gmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gmi ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GORS2_MOUSE GORS2_MOUSE]] Plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.<ref>PMID:10487747</ref>  [[http://www.uniprot.org/uniprot/JAM3_MOUSE JAM3_MOUSE]] Participates in cell-cell adhesion. It is a counter-receptor for ITGAM mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (By similarity). The soluble form is a mediator of angiogenesis.<ref>PMID:11739175</ref> <ref>PMID:15994945</ref> <ref>PMID:20592283</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Betzi, S]]
[[Category: Huang, X]]
[[Category: Huang, X]]
[[Category: Betzi, S]]
[[Category: Morelli, X]]
[[Category: Morelli, X]]
[[Category: Shi, N]]
[[Category: Shi, X]]
[[Category: Shi, X]]
[[Category: Shi, N]]
[[Category: Beta strand sandswish]]
[[Category: Classic pdz peptide binding groove]]
[[Category: Conserved carboxylate-binding loop]]
[[Category: Structural protein-peptide complex]]

Revision as of 16:42, 24 May 2017

Crystal Structure of GRASP55 GRASP domain in complex with JAM-C C-terminusCrystal Structure of GRASP55 GRASP domain in complex with JAM-C C-terminus

Structural highlights

5gmi is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GORS2_MOUSE] Plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.[1] [JAM3_MOUSE] Participates in cell-cell adhesion. It is a counter-receptor for ITGAM mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (By similarity). The soluble form is a mediator of angiogenesis.[2] [3] [4]

References

  1. ↑ Shorter J, Watson R, Giannakou ME, Clarke M, Warren G, Barr FA. GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. EMBO J. 1999 Sep 15;18(18):4949-60. PMID:10487747 doi:http://dx.doi.org/10.1093/emboj/18.18.4949
  2. ↑ Aurrand-Lions M, Johnson-Leger C, Wong C, Du Pasquier L, Imhof BA. Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members. Blood. 2001 Dec 15;98(13):3699-707. PMID:11739175
  3. ↑ Lamagna C, Hodivala-Dilke KM, Imhof BA, Aurrand-Lions M. Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth. Cancer Res. 2005 Jul 1;65(13):5703-10. PMID:15994945 doi:http://dx.doi.org/10.1158/0008-5472.CAN-04-4012
  4. ↑ Rabquer BJ, Amin MA, Teegala N, Shaheen MK, Tsou PS, Ruth JH, Lesch CA, Imhof BA, Koch AE. Junctional adhesion molecule-C is a soluble mediator of angiogenesis. J Immunol. 2010 Aug 1;185(3):1777-85. doi: 10.4049/jimmunol.1000556. Epub 2010, Jun 30. PMID:20592283 doi:10.4049/jimmunol.1000556

5gmi, resolution 2.71Å

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