1v3a: Difference between revisions

Revision as of 12:01, 3 May 2008

Structure of human PRL-3, the phosphatase associated with cancer metastasis

OverviewOverview

PRL-3, a novel class protein of prenylated tyrosine phosphatase, is important in cancer metastasis. Due to its high levels of expression in metastatic tumors, PRL-3 may constitute a useful marker for metastasis and might be a new therapeutic target. Here, we present the solution structure of the phosphatase domain of a human PRL-3 (residues 1-162) in phosphate-free state. The nuclear magnetic resonance (NMR) structure of PRL-3 is similar to that of other known phosphatases with minor differences in the secondary structure. But the conformation and flexibility of the loops comprising the active site differ significantly. When phosphate ions or sodium orthovanadate, which is a known inhibitor, are added to the apo PRL-3, the NMR signals from the residues in the active site appeared and could be assigned, indicating that the conformation of the residues has been stabilized.

About this StructureAbout this Structure

1V3A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of human PRL-3, the phosphatase associated with cancer metastasis., Kim KA, Song JS, Jee J, Sheen MR, Lee C, Lee TG, Ro S, Cho JM, Lee W, Yamazaki T, Jeon YH, Cheong C, FEBS Lett. 2004 May 7;565(1-3):181-7. PMID:15135076 Page seeded by OCA on Sat May 3 12:01:28 2008

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OCA

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 '''Structure of human PRL-3, the phosphatase associated with cancer metastasis'''
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 [[Category: Cheong, C.]]
 [[Category: Jeon, Y H.]]
-[[Category: hydrolase]]
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:01:28 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:18:53 2008''