Sandbox Reserved 1063: Difference between revisions

One of the two functional domains of AdcR is the <scene name='69/694230/Dimerization_domain/3'> dimerization domain</scene>. This domain connects and stabilizes the two pseudosymmetric dimers and is composed of the <scene name='69/694230/Alpha_1/1'>α1 helix</scene>, the C-terminus of the <scene name='69/694230/Alpha_five/1'>α5 helix</scene> , and the <scene name='69/694230/Alpha_6/1'>α6 helix</scene>. This domain is connected to the [https://en.wikipedia.org/wiki/DNA-binding_domain DNA binding domain] by the long α5 helix. The DNA binding domain stabilizes the major and minor groove of DNA via the <scene name='69/694230/Whth_4/7'>winged helix-turn-helix (wHTH)</scene> motif. The binding of Zinc to the <scene name='69/694230/2_binding_sites/4'>Zinc binding pocket</scene> induces a conformational change that allows for a <scene name='69/694230/Hydrogen_bonding_1/4'>hydrogen bond network</scene> between 4 specific residues that connect multiple helices from the metal binding pockets and DNA binding domain. It is believed that this hydrogen bond network is the allosteric activator needed to expose residues that bind the bases along the major groove of the DNA <ref name="guerra">PMID:22085181</ref>. The binding sites are found adjacent to the DNA binding domain.