5xa0: Difference between revisions

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-'''Unreleased structure'''
-The entry 5xa0 is ON HOLD  until Paper Publication
+==Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain==
+<StructureSection load='5xa0' size='340' side='right' caption='[[5xa0]], [[Resolution|resolution]] 5.81&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5xa0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XA0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x9z|5x9z]], [[5xa1|5xa1]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xa0 OCA], [http://pdbe.org/5xa0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xa0 RCSB], [http://www.ebi.ac.uk/pdbsum/5xa0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xa0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Hamada, K]]
+[[Category: Mikoshiba, K]]
+[[Category: Miyatake, H]]
+[[Category: Terauchi, A]]
+[[Category: Metal transport]]
+[[Category: Receptor channel calcium]]