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| <table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'> | | <span style='background-color: yellow;'>For additional information see '''2009, December:''' at [[Retractions and Fraud]].</span></br>REMOVED: The PDB entry 1g40 was removed. |
| WARNING: This structure was flagged as problematic. For additional information see '''2009, December:''' at [[Retractions and Fraud]].</td></tr></table>
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| ==CRYSTAL STRUCTURE OF A COMPLEMENT PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS==
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| <StructureSection load='1g40' size='340' side='right' caption='[[1g40]], [[Resolution|resolution]] 2.20Å' scene=''>
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| == Structural highlights ==
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| <table><tr><td colspan='2'>[[1g40]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1G40 FirstGlance]. <br>
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| </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g40 OCA], [http://pdbe.org/1g40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g40 RCSB], [http://www.ebi.ac.uk/pdbsum/1g40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1g40 ProSAT]</span></td></tr>
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| </table>
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| == Function ==
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| [[http://www.uniprot.org/uniprot/VCP_VACCW VCP_VACCW]] Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation. Binds C3b and C4b.<ref>PMID:1731333</ref> <ref>PMID:18287241</ref>
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| == Evolutionary Conservation ==
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| [[Image:Consurf_key_small.gif|200px|right]]
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| Check<jmol>
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| <jmolCheckbox>
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| <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/1g40_consurf.spt"</scriptWhenChecked>
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| <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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| <text>to colour the structure by Evolutionary Conservation</text>
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| </jmolCheckbox>
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| </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g40 ConSurf].
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| <div style="clear:both"></div>
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| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Vaccinia virus complement control protein (VCP) inhibits both pathways of complement activation through binding the third and fourth components. A homolog of mammalian regulators of complement activation, its ability to bind heparin endows VCP with additional activities of significance to viral infectivity. The structure of VCP reveals a highly extended molecule with a putative heparin recognition site at its C-terminal end. A second cluster of positive charges provides a possibly overlapping binding site for both heparin and complement components. Experiments suggested by the structure indicate that VCP can bind heparin and control complement simultaneously. This, the structure of any intact regulator of complement activation, along with attendant functional insights, will stimulate the design of new therapeutic inhibitors of complement.
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| Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans.,Murthy KH, Smith SA, Ganesh VK, Judge KW, Mullin N, Barlow PN, Ogata CM, Kotwal GJ Cell. 2001 Jan 26;104(2):301-11. PMID:11207370<ref>PMID:11207370</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 1g40" style="background-color:#fffaf0;"></div>
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| ==See Also==
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| *[[Retractions and Fraud|Retractions and Fraud]]
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Vaccinia virus]]
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| [[Category: Barlow, P N]]
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| [[Category: Ganesh, V K]]
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| [[Category: Judge, K W]]
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| [[Category: Kotwal, G K]]
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| [[Category: Mullin, N]]
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| [[Category: Murthy, K H.M]]
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| [[Category: Ogata, C M]]
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| [[Category: Smith, S A]]
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| [[Category: Beta]]
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| [[Category: Immune system]]
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| [[Category: Module]]
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