1tq1: Difference between revisions

Revision as of 13:21, 30 April 2008

Solution structure of At5g66040, a putative protein from Arabidosis Thaliana

OverviewOverview

We describe the three-dimensional structure of the product of Arabidopsis thaliana gene At5g66040.1 as determined by NMR spectroscopy. This protein is categorized as single-domain sulfurtransferase and is annotated as a senescence-associated protein (sen1-like protein) and ketoconazole resistance protein (http://arabidopsis.org/info/genefamily/STR_genefamily.html). The sequence of At5g66040.1 is virtually identical to that of a protein from Arabidopsis found by others to confer ketoconazole resistance in yeast. Comparison of the three-dimensional structure with those in the Protein Data Bank revealed that At5g66040.1 contains an additional mobile beta-hairpin not found in other rhodaneses that may function in binding specific substrates. This represents the first structure of a single-domain plant sulfurtransferase. The enzymatically active cysteine-containing domain belongs to the CDC25 class of phosphatases, sulfide dehydrogenases, and stress proteins such as senescence specific protein 1 in plants, PspE and GlpE in bacteria, and cyanide and arsenate resistance proteins. Versions of this domain that lack the active site cysteine are found in other proteins, such as phosphatases, ubiquitin hydrolases, and sulfuryltransferases.

About this StructureAbout this Structure

1TQ1 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

ReferenceReference

Solution structure of a single-domain thiosulfate sulfurtransferase from Arabidopsis thaliana., Cornilescu G, Vinarov DA, Tyler EM, Markley JL, Cornilescu CC, Protein Sci. 2006 Dec;15(12):2836-41. Epub 2006 Nov 6. PMID:17088324 Page seeded by OCA on Wed Apr 30 13:21:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1tq1.jpg|left|200px]]
- {{Structure
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-}}
 '''Solution structure of At5g66040, a putative protein from Arabidosis Thaliana'''
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 [[Category: Tyler, E M.]]
 [[Category: Vinarov, D.]]
-[[Category: at5g66040]]
+[[Category: At5g66040]]
-[[Category: center for eukaryotic structural genomic]]
+[[Category: Center for eukaryotic structural genomic]]
-[[Category: cesg]]
+[[Category: Cesg]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi]]
+[[Category: Psi]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
-[[Category: unknown function]]
+[[Category: Unknown function]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:21:07 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:30 2008''