5ptf: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5ptf is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 158)==
 
<StructureSection load='5ptf' size='340' side='right' caption='[[5ptf]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
Authors: Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ptf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PTF FirstGlance]. <br>
Description: PanDDA analysis group deposition --Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 158)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ptf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ptf OCA], [http://pdbe.org/5ptf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ptf RCSB], [http://www.ebi.ac.uk/pdbsum/5ptf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ptf ProSAT]</span></td></tr>
[[Category: Pearce, N.M]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bradley, A R]]
[[Category: Brandao-Neto, J]]
[[Category: Brennan, P E]]
[[Category: Collins, P]]
[[Category: Collins, P]]
[[Category: Cox, O]]
[[Category: Cox, O]]
[[Category: Arrowsmith, C.H]]
[[Category: Delft, F von]]
[[Category: Brandao-Neto, J]]
[[Category: Dias, A]]
[[Category: Douangamath, A]]
[[Category: Edwards, A]]
[[Category: Fairhead, M]]
[[Category: Fairhead, M]]
[[Category: Von Delft, F]]
[[Category: Krojer, T]]
[[Category: MacLean, E]]
[[Category: Ng, J]]
[[Category: Pearce, N M]]
[[Category: Renjie, Z]]
[[Category: Renjie, Z]]
[[Category: Sethi, R]]
[[Category: Talon, R]]
[[Category: Wright, N]]
[[Category: Wright, N]]
[[Category: Ng, J]]
[[Category: Bromodomain]]
[[Category: Bradley, A.R]]
[[Category: Epigenetic]]
[[Category: Talon, R]]
[[Category: Gene regulation]]
[[Category: Brennan, P.E]]
[[Category: Pandda]]
[[Category: Edwards, A]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Douangamath, A]]
[[Category: Xchemexplorer]]
[[Category: Maclean, E]]
[[Category: Krojer, T]]
[[Category: Dias, A]]
[[Category: Sethi, R]]
[[Category: Bountra, C]]

Revision as of 16:57, 29 March 2017

PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 158)PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 158)

Structural highlights

5ptf is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.[1] [2]

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem. 2011 Oct 21;286(42):36944-55. doi: 10.1074/jbc.M111.244400. Epub, 2011 Aug 31. PMID:21880731 doi:http://dx.doi.org/10.1074/jbc.M111.244400

5ptf, resolution 1.49Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5ptf&oldid=2733439"