5uvw: Difference between revisions

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'''Unreleased structure'''


The entry 5uvw is ON HOLD  until Feb 20 2019
==BRD4_Bromodomain1-A1376855==
 
<StructureSection load='5uvw' size='340' side='right' caption='[[5uvw]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
Authors: Park, C.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5uvw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UVW FirstGlance]. <br>
Description: BRD4_Bromodomain1-A1376855
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8NG:N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide'>8NG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uvv|5uvv]], [[5uvz|5uvz]], [[5uvx|5uvx]], [[5uvy|5uvy]], [[5uvs|5uvs]], [[5uvu|5uvu]], [[5uvt|5uvt]]</td></tr>
[[Category: Park, C.H]]
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uvw OCA], [http://pdbe.org/5uvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uvw RCSB], [http://www.ebi.ac.uk/pdbsum/5uvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uvw ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Park, C H]]
[[Category: Helix bundle brd4 bromodomain 1 - inhibitor complex three complexes per asymmetric unit]]
[[Category: Signaling protein-inhibitor complex]]

Revision as of 12:02, 16 November 2017

BRD4_Bromodomain1-A1376855BRD4_Bromodomain1-A1376855

Structural highlights

5uvw is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:BRD4, HUNK1 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

References

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

5uvw, resolution 2.14Å

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