1sum: Difference between revisions

Revision as of 09:09, 3 May 2008

Crystal structure of a hypothetical protein at 2.0 A resolution

OverviewOverview

PhoU proteins are known to play a role in the regulation of phosphate uptake. In Thermotoga maritima, two PhoU homologues have been identified bioinformatically. Here we report the crystal structure of one of the PhoU homologues at 2.0 A resolution. The structure of the PhoU protein homologue contains a highly symmetric new structural fold composed of two repeats of a three-helix bundle. The structure unexpectedly revealed a trinuclear and a tetranuclear iron cluster that were found to be bound on the surface. Each of the two multinuclear iron clusters is coordinated by a conserved E(D)XXXD motif pair. Our structure reveals a new class of metalloprotein containing multinuclear iron clusters. The possible functional implication based on the structure are discussed.

About this StructureAbout this Structure

1SUM is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters., Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH, J Biol Chem. 2005 Apr 22;280(16):15960-6. Epub 2005 Feb 16. PMID:15716271 Page seeded by OCA on Sat May 3 09:09:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1sum.gif|left|200px]]
- {{Structure
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-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01895 PhoU], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0704 PhoU]</span>
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sum OCA], [http://www.ebi.ac.uk/pdbsum/1sum PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sum RCSB]</span>
-}}
 '''Crystal structure of a hypothetical protein at 2.0 A resolution'''
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 [[Category: Lou, Y.]]
 [[Category: Yokota, H.]]
-[[Category: abc transport]]
+[[Category: Abc transport]]
-[[Category: berkeley structural genomics center]]
+[[Category: Berkeley structural genomics center]]
-[[Category: bsgc]]
+[[Category: Bsgc]]
-[[Category: phou]]
+[[Category: Phou]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi]]
+[[Category: Psi]]
-[[Category: pst]]
+[[Category: Pst]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
-[[Category: structure funded by nih]]
+[[Category: Structure funded by nih]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:09:07 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:12 2008''