1ssk: Difference between revisions

Revision as of 09:05, 3 May 2008

Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein

OverviewOverview

The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site.

About this StructureAbout this Structure

1SSK is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein., Huang Q, Yu L, Petros AM, Gunasekera A, Liu Z, Xu N, Hajduk P, Mack J, Fesik SW, Olejniczak ET, Biochemistry. 2004 May 25;43(20):6059-63. PMID:15147189 Page seeded by OCA on Sat May 3 09:05:33 2008

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OCA

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 [[Category: Xu, N.]]
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-[[Category: nucleocapsid protein]]
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:05:33 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:46:24 2008''