Mutations in BRCA1/BARD1 RING-domain heterodimer: Difference between revisions

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*<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>.
*<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>.


To begin with scenes, please click the green link with the name of the mutation.
*<scene name='75/751104/L22s/3'>Mutation L22S: </scene> <jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. Putative new hydrogen bonds were added. <scene name='75/751104/L22s/6'>TextToBeDisplayed</scene>


'''MY EXAMPLE:'''
*<scene name='75/751104/L22s/3'>Mutation L22S: </scene>  
<scene name='75/751104/L22s/6'>Should be with green halos</scene>.
<jmol>
 
<jmolLink>
*<scene name='75/751104/L22s/5'>Mutation L22S: </scene> <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. <jmol><jmolButton><script>if (_animating); anim pause;set echo bottom left; color echo white; font echo 20 sansserif;echo Animation Paused; else; anim resume; set echo off;endif;</script> <text>Toggle Animation</text></jmolButton></jmol> N.b. putative new hydrogen bonds were added.
  <script>
    animation on; animation mode loop; frame 1 1 play; animation off; frame 1;
  </script>
<text>Wild type conformation,</text>
</jmolLink>
</jmol>
and this renders the
<jmol>
<jmolLink>
  <script>
    animation on; animation mode loop; frame 2 2 play; animation off; frame 2;
  </script>
  <text>Mutation
  </text>
</jmolLink>
</jmol>
Click here to see the
<jmol>
<jmolLink>
  <script>
    animation off; frame all
  </script>
  <text>Mutated and wildtype residues
  </text>
</jmolLink>
</jmol> together. Click here to  
<jmol>
<jmolLink>
  <script>
  animation on; animation mode loop; frame play
  </script>
  <text>see animation
  </text>
</jmolLink>
</jmol> of both states. Putative new hydrogen bonds were added.


To begin with scenes, please click in the following order: on "Wild type", after that "Mutation" and so on.
To begin with scenes, please click in the following order: on "Wild type", after that "Mutation" and so on.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Joel L. Sussman, Michal Harel