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==Structure of T4Pnkp 3' phosphatase covalently bound to BeF3== | |||
<StructureSection load='5uj0' size='340' side='right' caption='[[5uj0]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5uj0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJ0 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj0 OCA], [http://pdbe.org/5uj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uj0 RCSB], [http://www.ebi.ac.uk/pdbsum/5uj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/KIPN_BPT4 KIPN_BPT4]] Acts as a 5'-hydroxyl kinase, a 3'-phosphatase and a 2',3'-cyclic phosphodiesterase. Catalyzes the transfer of the terminal phosphate of ATP to the 5'-hydroxyl termini of ribo- and deoxyribonucleotides. In the presence of ADP the enzyme also catalyzes an exchange reaction. In the exchange reaction, an excess ADP causes the enzyme to transfer the 5' terminal phosphate from phosphorylated DNA to ADP. These activities modify the ends of nicked tRNA generated by a bacterial response to infection and facilitate repair by T4 RNA ligase. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chatterjee, D]] | |||
[[Category: Shuman, S]] | |||
[[Category: Bef3-bound]] | |||
[[Category: Beryllium]] | |||
[[Category: Hydrolase]] | |||
[[Category: Phosphatase]] | |||
[[Category: Pnkp]] | |||
[[Category: Transferase]] | |||
Revision as of 12:30, 10 March 2017
Structure of T4Pnkp 3' phosphatase covalently bound to BeF3Structure of T4Pnkp 3' phosphatase covalently bound to BeF3
Structural highlights
Function[KIPN_BPT4] Acts as a 5'-hydroxyl kinase, a 3'-phosphatase and a 2',3'-cyclic phosphodiesterase. Catalyzes the transfer of the terminal phosphate of ATP to the 5'-hydroxyl termini of ribo- and deoxyribonucleotides. In the presence of ADP the enzyme also catalyzes an exchange reaction. In the exchange reaction, an excess ADP causes the enzyme to transfer the 5' terminal phosphate from phosphorylated DNA to ADP. These activities modify the ends of nicked tRNA generated by a bacterial response to infection and facilitate repair by T4 RNA ligase. |
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