Mutations in BRCA1/BARD1 RING-domain heterodimer: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Joel L. Sussman, Michal Harel

@@ Line 8: / Line 8: @@
 *<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>.
 To begin with scenes, please click in the following order: "Mutation ...", after that on "Wild type", "Mutation" and so on.
-*<scene name='75/751104/L22s/3'>Mutation L22S</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/L22s/2'>Click here to see animation of this scene</scene>. ([[1jm7]]). Putative new hydrogen bonds were added.
+*'''Mutation L22S''': <scene name='75/751104/L22s/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/L22s/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/L22s/2'>Click here to see animation of this scene</scene>. ([[1jm7]]). Putative new hydrogen bonds were added.
 *<scene name='75/751104/T37k/1'>Mutation T37K</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/T37k/2'>Click here to see animation of this scene</scene>. ([[1jm7]]).
 *<scene name='75/751104/Cv/15'>Mutation C39R</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/16'>Click here to see animation of this scene</scene>. ([[1jm7]]). This mutation causes missing of S-Zn bond.