IGF1: Difference between revisions
No edit summary |
No edit summary |
||
| Line 76: | Line 76: | ||
Growth failure, diabetes, cardiovascular pathology and others diseases such as Laron syndrom or cancers can be the consequences of an '''IGF-1 low level'''. | Growth failure, diabetes, cardiovascular pathology and others diseases such as Laron syndrom or cancers can be the consequences of an '''IGF-1 low level'''. | ||
Knowing that IGF-1 leads to cell proliferation with apoptose inhibition, if DNA undergoes alterations or mutations, those alterated cells will proliferate and survive even though it should result in their elimination by apoptose. | Knowing that IGF-1 leads to cell proliferation with apoptose inhibition, if DNA undergoes alterations or mutations, those alterated cells will proliferate and survive even though it should result in their elimination by apoptose. | ||
Hence inducing '''cancer proliferation'''. <ref>R. Kaaks, Médecine Nucléaire - Imagerie fonctionnelle et métabolique, 2003, vol.27, n°1</ref> | Hence inducing '''cancer proliferation'''. <ref>R. Kaaks, Médecine Nucléaire - Imagerie fonctionnelle et métabolique, 2003, vol.27, n°1</ref> | ||