P53: Difference between revisions
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<StructureSection load='1tup' size='350' side='right' scene='26/26327/Initl/2' caption='Human p53 DNA-binding domain complex with DNA and Zn+2 ions (grey) (PDB | <StructureSection load='1tup' size='350' side='right' scene='26/26327/Initl/2' caption='Human p53 DNA-binding domain complex with DNA and Zn+2 ions (grey) (PDB Code [[1tup]])'> | ||
[[Image:P53_DNA.png|left|200px]] | [[Image:P53_DNA.png|left|200px]] | ||
__TOC__ | __TOC__ | ||
== | ==p53 Tumor Suppressor Protein (PDB ID [[1tup]])== | ||
'''p53''' is a tumor suppressor. In the absence of cellular stress, p53 does not exert effect on cell fate, but under stress, p53 becomes activated and causes phenotypic changes in cells like senescence and apoptosis<ref>PMID:12719720</ref>. Many human cancer cells carry mutated p53<ref>PMID:20182618</ref>. The name '''p53''' refers to its apparent molecular mass. It runs as a 53 kDa molecule on SDS-PAGE. But based on calculations from its amino acid residues, p53's mass is actually 43.7 kDa. This difference may be due to the high number of proline residues in the protein, resulting in its migrating slowly on SDS-PAGE. | '''p53''' is a tumor suppressor. In the absence of cellular stress, p53 does not exert effect on cell fate, but under stress, p53 becomes activated and causes phenotypic changes in cells like senescence and apoptosis<ref>PMID:12719720</ref>. Many human cancer cells carry mutated p53<ref>PMID:20182618</ref>. The name '''p53''' refers to its apparent molecular mass. It runs as a 53 kDa molecule on SDS-PAGE. But based on calculations from its amino acid residues, p53's mass is actually 43.7 kDa. This difference may be due to the high number of proline residues in the protein, resulting in its migrating slowly on SDS-PAGE. | ||