Estrogen receptor: Difference between revisions
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'''Estrogen receptors''' (ER) are activated by the hormone estrogen (EST). The activated ER binds DNA and regulates the activity of many genes. There are 2 forms of ER: α and β and ER dimers can be of αα, ββ and αβ. ER is composed of 5 domains: N terminal A/B domain can transactivate transcription without binding estrogen; C domain (DBD) binds to Estrogen response elements of DNA; D domain is a hinge region; E domain is ligand binding (LBD) as well as binding the coactivator and corepressor proteins and transactivates gene transcription.<br /> | '''Estrogen receptors''' (ER) are activated by the hormone estrogen (EST). The activated ER binds DNA and regulates the activity of many genes. There are 2 forms of ER: α and β and ER dimers can be of αα, ββ and αβ. ER is composed of 5 domains: N terminal A/B domain can transactivate transcription without binding estrogen; C domain (DBD) binds to Estrogen response elements of DNA; D domain is a hinge region; E domain is ligand binding (LBD) as well as binding the coactivator and corepressor proteins and transactivates gene transcription.<br /> | ||
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==For more details see== | |||
[[Ivan Koutsopatriy estrogen receptor]]<br /> | |||
[[C-di-GMP receptors with PilZ domain]]<br /> | |||
For more details on ERβ see [[Student Project 10 for UMass Chemistry 423 Spring 2015]]<br /> | |||
For more details on ER-Tamoxifen complex see [[Tamoxifen]]. | |||
==3D structures of estrogen receptor== | ==3D structures of estrogen receptor== | ||