SAICAR synthetase: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='4fe2' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''SAICAR synthetase''' (SAI) or '''phosphoribosylaminoimidazole-succi... |
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<StructureSection load='4fe2' size='340' side='right' caption='SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code [[4fe2]]) ' scene=''> | |||
<StructureSection load='4fe2' size='340' side='right' caption=' | |||
== Function == | == Function == | ||
'''SAICAR synthetase''' (SAI) or '''phosphoribosylaminoimidazole-succinocarboxamide synthetase''' is part of the purine biosynthesis. SAI catalyzes ATP-dependent ligation of carboxyaminoimidazole ribotide (AICAR) with aspartate<ref>PMID:26072057</ref>. | '''SAICAR synthetase''' (SAI) or '''phosphoribosylaminoimidazole-succinocarboxamide synthetase''' is part of the purine biosynthesis. SAI catalyzes ATP-dependent ligation of carboxyaminoimidazole ribotide (AICAR) with aspartate<ref>PMID:26072057</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
SAI structure shows two domains. The active site is located in a hydrophilic tunnel between the 2 domains and contains ADP, aspartic acid and aminoimidazole-ribonucleotide (AIR)<ref>PMID:24598753</ref>. | |||
</StructureSection> | </StructureSection> | ||
==3D structures of | ==3D structures of SAICAR synthetase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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**[[1a48]] – ySAI - yeast<br /> | **[[1a48]] – ySAI - yeast<br /> | ||
**[[3r9r]] – SAI – Mycobacterium abscessus <br /> | **[[3r9r]] – SAI – ''Mycobacterium abscessus'' <br /> | ||
**[[3kre]] – SAI – Ehrlichia chaffeensis <br /> | **[[3kre]] – SAI – ''Ehrlichia chaffeensis'' <br /> | ||
**[[1kut]] – SAI – Thermotoga maritima<br /> | **[[1kut]] – SAI – ''Thermotoga maritima''<br /> | ||
*SAICAR synthetase complex | *SAICAR synthetase complex | ||
**[[2yzl]] – MjSAI + ADP – Methanocalcococcus jannaschii <br /> | **[[2yzl]] – MjSAI + ADP – ''Methanocalcococcus jannaschii'' <br /> | ||
**[[2z02]] – MjSAI + ATP <br /> | **[[2z02]] – MjSAI + ATP <br /> | ||
**[[4fe2]], [[4nye]] – SpSAI + ADP + aspartate + AICAR – ''Streptococcus pneumoniae''<br /> | |||
**[[4fgr]] – SpSAI + ADP <br /> | **[[4fgr]] – SpSAI + ADP <br /> | ||
**[[3nua]] – SAI + ADP + AMP – Clostridium perfringens<br /> | **[[3nua]] – SAI + ADP + AMP – ''Clostridium perfringens''<br /> | ||
**[[2ywv]] – SAI + ADP – Geobsacillus kaustophilus<br /> | **[[2ywv]] – SAI + ADP – ''Geobsacillus kaustophilus''<br /> | ||
**[[2cnq]] – ySAI + ADP + AMP + succinate + AICAR <br /> | **[[2cnq]] – ySAI + ADP + AMP + succinate + AICAR <br /> | ||
**[[2cnv]] – ySAI + aspartate + AICAR derivative<br /> | **[[2cnv]] – ySAI + aspartate + AICAR derivative<br /> | ||
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**[[1obd]] – ySAI + ATP + AMP<br /> | **[[1obd]] – ySAI + ATP + AMP<br /> | ||
**[[1obg]] – ySAI + AMP<br /> | **[[1obg]] – ySAI + AMP<br /> | ||
**[[2gqr]] – EcSAI + ADP – Escherichia coli<br /> | **[[2gqr]] – EcSAI + ADP – ''Escherichia coli''<br /> | ||
**[[2gqs]] – EcSAI + ADP + AICAR <br /> | **[[2gqs]] – EcSAI + ADP + AICAR <br /> | ||
*SAICAR synthetase type-1 | *SAICAR synthetase type-1 | ||
**[[3u54]] – PhSAI – Pyrococcus horikoshii<br /> | **[[3u54]] – PhSAI – ''Pyrococcus horikoshii''<br /> | ||
**[[4o81]], [[4o82]], [[4o83]] – PhSAI + ADP + AMP <br /> | **[[4o81]], [[4o82]], [[4o83]] – PhSAI + ADP + AMP <br /> | ||
**[[4o84]] – PhSAI + GMP <br /> | **[[4o84]] – PhSAI + GMP <br /> | ||