4idl: Difference between revisions
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==Low melting temperature Anti-Cholera Toxin Llama VHH domain== | ==Low melting temperature Anti-Cholera Toxin Llama VHH domain== | ||
<StructureSection load='4idl' size='340' side='right' caption='[[4idl]], [[Resolution|resolution]] 2.09Å' scene=''> | <StructureSection load='4idl' size='340' side='right'caption='[[4idl]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4idl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IDL FirstGlance]. <br> | <table><tr><td colspan='2'>[[4idl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IDL FirstGlance]. <br> | ||
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==See Also== | ==See Also== | ||
*[[3D structures | *[[Antibody 3D structures|Antibody 3D structures]] | ||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Camelus glama]] | [[Category: Camelus glama]] | ||
[[Category: Large Structures]] | |||
[[Category: Hol, W G.J]] | [[Category: Hol, W G.J]] | ||
[[Category: Lam, A]] | [[Category: Lam, A]] | ||
Revision as of 10:42, 27 March 2019
Low melting temperature Anti-Cholera Toxin Llama VHH domainLow melting temperature Anti-Cholera Toxin Llama VHH domain
Structural highlights
Publication Abstract from PubMedVariable heavy domains derived from the heavy-chain-only antibodies found in camelids (V(H)H domains) are known for their thermal stability. Here, the structure of A9, an anti-cholera toxin V(H)H domain (K(d) = 77 +/- 5 nM) that has an unusually low melting temperature of 319.9 +/- 1.6 K, is reported. The CDR3 residues of A9 form a beta-hairpin that is directed away from the former V(H)-V(L) interfacial surface, exposing hydrophobic residues to the solvent. A DALI structural similarity search showed that this CDR3 conformation is uncommon. Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain.,Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):90-3. doi: , 10.1107/S1744309112050750. Epub 2013 Jan 26. PMID:23385744[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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