4mah: Difference between revisions
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==Structure of Aspergillus oryzae AA11 Lytic Polysaccharide Monooxygenase with Zn== | ==Structure of Aspergillus oryzae AA11 Lytic Polysaccharide Monooxygenase with Zn== | ||
<StructureSection load='4mah' size='340' side='right' caption='[[4mah]], [[Resolution|resolution]] 1.55Å' scene=''> | <StructureSection load='4mah' size='340' side='right'caption='[[4mah]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mah]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4mah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_oryzae Aspergillus oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MAH FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mah OCA], [https://pdbe.org/4mah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mah RCSB], [https://www.ebi.ac.uk/pdbsum/4mah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mah ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q2UA85_ASPOR Q2UA85_ASPOR] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4mah" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4mah" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Aspergillus oryzae]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Davies GJ]] | ||
[[Category: | [[Category: Hemsworth GR]] | ||
[[Category: | [[Category: Henrissat B]] | ||
[[Category: | [[Category: Walton PH]] | ||
Revision as of 14:06, 21 December 2022
Structure of Aspergillus oryzae AA11 Lytic Polysaccharide Monooxygenase with ZnStructure of Aspergillus oryzae AA11 Lytic Polysaccharide Monooxygenase with Zn
Structural highlights
FunctionPublication Abstract from PubMedLytic polysaccharide monooxygenases (LPMOs) are a recently discovered class of enzymes capable of oxidizing recalcitrant polysaccharides. They are attracting considerable attention owing to their potential use in biomass conversion, notably in the production of biofuels. Previous studies have identified two discrete sequence-based families of these enzymes termed AA9 (formerly GH61) and AA10 (formerly CBM33). Here, we report the discovery of a third family of LPMOs. Using a chitin-degrading exemplar from Aspergillus oryzae, we show that the three-dimensional structure of the enzyme shares some features of the previous two classes of LPMOs, including a copper active center featuring the 'histidine brace' active site, but is distinct in terms of its active site details and its EPR spectroscopy. The newly characterized AA11 family expands the LPMO clan, potentially broadening both the range of potential substrates and the types of reactive copper-oxygen species formed at the active site of LPMOs. Discovery and characterization of a new family of lytic polysaccharide monooxygenases.,Hemsworth GR, Henrissat B, Davies GJ, Walton PH Nat Chem Biol. 2014 Feb;10(2):122-6. doi: 10.1038/nchembio.1417. Epub 2013 Dec, 22. PMID:24362702[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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