5u4x: Difference between revisions
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==Coactivator-associated arginine methyltransferase 1== | ==Coactivator-associated arginine methyltransferase 1 with TP-064== | ||
<StructureSection load='5u4x' size='340' side='right' caption='[[5u4x]], [[Resolution|resolution]] 1.88Å' scene=''> | <StructureSection load='5u4x' size='340' side='right' caption='[[5u4x]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5u4x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U4X FirstGlance]. <br> | <table><tr><td colspan='2'>[[5u4x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U4X FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7VM:N-METHYL-N-[(2-{1-[2-(METHYLAMINO)ETHYL]PIPERIDIN-4-YL}PYRIDIN-4-YL)METHYL]-3-PHENOXYBENZAMIDE'>7VM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7VM:N-METHYL-N-[(2-{1-[2-(METHYLAMINO)ETHYL]PIPERIDIN-4-YL}PYRIDIN-4-YL)METHYL]-3-PHENOXYBENZAMIDE'>7VM</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CARM1, PRMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_I_protein_arginine_methyltransferase Type I protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.319 2.1.1.319] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_I_protein_arginine_methyltransferase Type I protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.319 2.1.1.319] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4x OCA], [http://pdbe.org/5u4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4x RCSB], [http://www.ebi.ac.uk/pdbsum/5u4x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4x ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4x OCA], [http://pdbe.org/5u4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4x RCSB], [http://www.ebi.ac.uk/pdbsum/5u4x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4x ProSAT]</span></td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Type I protein arginine methyltransferase]] | [[Category: Type I protein arginine methyltransferase]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
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[[Category: DONG, A]] | [[Category: DONG, A]] | ||
[[Category: Edwards, A M]] | [[Category: Edwards, A M]] | ||
[[Category: Hutchinson, A]] | |||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: STONE, H]] | [[Category: STONE, H]] | ||
[[Category: Saikatendu, K S]] | [[Category: Saikatendu, K S]] | ||
[[Category: Seitova, A]] | |||
[[Category: WALKER, J R]] | [[Category: WALKER, J R]] | ||
[[Category: WU, H]] | [[Category: WU, H]] | ||
Revision as of 23:47, 24 January 2018
Coactivator-associated arginine methyltransferase 1 with TP-064Coactivator-associated arginine methyltransferase 1 with TP-064
Structural highlights
Function[CARM1_HUMAN] Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.[1] [2] References
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