Survivin: Difference between revisions

Revision as of 13:03, 14 June 2017

Function

Survivin or apoptosis inhibitor 4 (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation^[1]. Survivin is part of the chromosomal passanger complex (CPC) which includes also Borealin and INCENP ^[2].

Disease

IAP4 is found in human cancer cells^[3]. and can serve as a cancer marker and as a target for chemotherapy^[4].

Structure of human survivin dimer (magenta and green) complex with histone H3 peptide (cyan) and Zn+2 ion (grey) (PDB code 3uig).

Drag the structure with the mouse to rotate

3D structures of survivin3D structures of survivin

Updated on 14-June-2017

ReferencesReferences

↑ Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20. PMID:9850056
↑ Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. PMID:23175282 doi:http://dx.doi.org/10.1038/nrm3474
↑ Zaffaroni N, Costa A, Pennati M, De Marco C, Affini E, Madeo M, Erdas R, Cabras A, Kusamura S, Baratti D, Deraco M, Daidone MG. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol. 2007;29(6):453-66. PMID:18032822
↑ Rodel F, Sprenger T, Kaina B, Liersch T, Rodel C, Fulda S, Hehlgans S. Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 2012;19(22):3679-88. PMID:22680927

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20. PMID:9850056

[2] Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012 Dec;13(12):789-803. doi: 10.1038/nrm3474. PMID:23175282 doi:http://dx.doi.org/10.1038/nrm3474

[3] Zaffaroni N, Costa A, Pennati M, De Marco C, Affini E, Madeo M, Erdas R, Cabras A, Kusamura S, Baratti D, Deraco M, Daidone MG. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol. 2007;29(6):453-66. PMID:18032822

[4] Rodel F, Sprenger T, Kaina B, Liersch T, Rodel C, Fulda S, Hehlgans S. Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 2012;19(22):3679-88. PMID:22680927

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Revision as of 14:24, 19 December 2016 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 13:03, 14 June 2017 view source Alexander Berchansky (talk \| contribs) 29,637 edits No edit summary Newer edit →
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	<StructureSection load='3uig' size='340' side='right' caption='Structure of human survivin dimer (~~grey~~ and green) complex with histone H3 peptide (cyan) and Zn+2 ion (grey) (PDB code [[3uig]]).' scene=''>		<StructureSection load='3uig' size='340' side='right' caption='Structure of human survivin dimer (magenta and green) complex with histone H3 peptide (cyan) and Zn+2 ion (grey) (PDB code [[3uig]]).' scene='59/596423/Cv/1'>

	== Function ==		== Function ==