1qup: Difference between revisions

Revision as of 06:43, 3 May 2008

CRYSTAL STRUCTURE OF THE COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE

OverviewOverview

Cellular systems for handling transition metal ions have been identified, but little is known about the structure and function of the specific trafficking proteins. The 1.8 A resolution structure of the yeast copper chaperone for superoxide dismutase (yCCS) reveals a protein composed of two domains. The N-terminal domain is very similar to the metallochaperone protein Atx1 and is likely to play a role in copper delivery and/or uptake. The second domain resembles the physiological target of yCCS, superoxide dismutase I (SOD1), in overall fold, but lacks all of the structural elements involved in catalysis. In the crystal, two SOD1-like domains interact to form a dimer. The subunit interface is remarkably similar to that in SOD1, suggesting a structural basis for target recognition by this metallochaperone.

About this StructureAbout this Structure

1QUP is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the copper chaperone for superoxide dismutase., Lamb AL, Wernimont AK, Pufahl RA, Culotta VC, O'Halloran TV, Rosenzweig AC, Nat Struct Biol. 1999 Aug;6(8):724-9. PMID:10426947 Page seeded by OCA on Sat May 3 06:43:40 2008

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OCA

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 [[Image:1qup.jpg|left|200px]]
- {{Structure
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 '''CRYSTAL STRUCTURE OF THE COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE'''
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 [[Category: Rosenzweig, A C.]]
 [[Category: Wernimont, A K.]]
-[[Category: beta-alpha-beta-beta-alpha-beta and beta barrel]]
+[[Category: Beta-alpha-beta-beta-alpha-beta and beta barrel]]
-[[Category: two domain]]
+[[Category: Two domain]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:43:40 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:19:18 2008''