3p6h: Difference between revisions
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==Human adipocyte lipid-binding protein FABP4 in complex with (S)-ibuprofen== | ==Human adipocyte lipid-binding protein FABP4 in complex with (S)-ibuprofen== | ||
<StructureSection load='3p6h' size='340' side='right' caption='[[3p6h]], [[Resolution|resolution]] 1.15Å' scene=''> | <StructureSection load='3p6h' size='340' side='right'caption='[[3p6h]], [[Resolution|resolution]] 1.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3p6h]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3p6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P6H FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p6c|3p6c]], [[3p6d|3p6d]], [[3p6e|3p6e]], [[3p6f|3p6f]], [[3p6g|3p6g]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3p6c|3p6c]], [[3p6d|3p6d]], [[3p6e|3p6e]], [[3p6f|3p6f]], [[3p6g|3p6g]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP4 ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6h OCA], [https://pdbe.org/3p6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p6h RCSB], [https://www.ebi.ac.uk/pdbsum/3p6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN]] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Fatty acid-binding protein|Fatty acid-binding protein]] | *[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Gonzalez, J M]] | [[Category: Gonzalez, J M]] | ||
[[Category: Pozharski, E]] | [[Category: Pozharski, E]] | ||
Revision as of 14:22, 18 May 2022
Human adipocyte lipid-binding protein FABP4 in complex with (S)-ibuprofenHuman adipocyte lipid-binding protein FABP4 in complex with (S)-ibuprofen
Structural highlights
Function[FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Publication Abstract from PubMedInhibition of human adipocyte fatty-acid binding protein (FABP4) has been proposed as a treatment for type 2 diabetes, fatty liver disease and atherosclerosis. However, FABP4 displays a naturally low selectivity towards hydrophobic ligands, leading to the possibility of side effects arising from cross-inhibition of other FABP isoforms. In a search for structural determinants of ligand-binding selectivity, the binding of FABP4 towards a group of small molecules structurally related to the nonsteroidal anti-inflammatory drug ibuprofen was analyzed through X-ray crystallography. Several specific hydrophobic interactions are shown to enhance the binding affinities of these compounds, whereas an aromatic edge-to-face interaction is proposed to determine the conformation of bound ligands, highlighting the importance of aromatic interactions in hydrophobic environments. Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4).,Gonzalez JM, Fisher SZ Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):163-70. doi:, 10.1107/S2053230X14027897. Epub 2015 Jan 28. PMID:25664790[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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