5tjb: Difference between revisions

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'''Unreleased structure'''


The entry 5tjb is ON HOLD until Paper Publication
==I-II linker of TRPML1 channel at pH 4.5==
 
<StructureSection load='5tjb' size='340' side='right' caption='[[5tjb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5tjb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TJB FirstGlance]. <br>
Description:  
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tja|5tja]], [[5tjc|5tjc]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tjb OCA], [http://pdbe.org/5tjb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tjb RCSB], [http://www.ebi.ac.uk/pdbsum/5tjb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tjb ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN]] Mucolipidosis type 4. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN]] Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.<ref>PMID:12459486</ref> <ref>PMID:14749347</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Benvin, N M]]
[[Category: Li, H]]
[[Category: Li, M]]
[[Category: Li, X]]
[[Category: Michailidis, I E]]
[[Category: Su, D]]
[[Category: Tong, L]]
[[Category: Wang, S]]
[[Category: Yang, J]]
[[Category: Zhang, W K]]
[[Category: Zhou, X]]
[[Category: Calcium and ph regulation]]
[[Category: Endolysosomal lumen]]
[[Category: Tetramer]]
[[Category: Transport protein]]

Revision as of 02:46, 26 January 2017

I-II linker of TRPML1 channel at pH 4.5I-II linker of TRPML1 channel at pH 4.5

Structural highlights

5tjb is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[MCLN1_HUMAN] Mucolipidosis type 4. The disease is caused by mutations affecting the gene represented in this entry.

Function

[MCLN1_HUMAN] Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.[1] [2]

References

  1. ↑ LaPlante JM, Falardeau J, Sun M, Kanazirska M, Brown EM, Slaugenhaupt SA, Vassilev PM. Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway. FEBS Lett. 2002 Dec 4;532(1-2):183-7. PMID:12459486
  2. ↑ Raychowdhury MK, Gonzalez-Perrett S, Montalbetti N, Timpanaro GA, Chasan B, Goldmann WH, Stahl S, Cooney A, Goldin E, Cantiello HF. Molecular pathophysiology of mucolipidosis type IV: pH dysregulation of the mucolipin-1 cation channel. Hum Mol Genet. 2004 Mar 15;13(6):617-27. Epub 2004 Jan 28. PMID:14749347 doi:http://dx.doi.org/10.1093/hmg/ddh067

5tjb, resolution 2.40Å

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OCA
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