User:Kerry Frattarola/Sandbox 1: Difference between revisions
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==Structure== | ==Structure== | ||
[[Crixivan]], also known as Indinavir, is an antiviral compound that acts as a protease inhibitor. The <scene name='74/745991/Crixivan/2'>structure</scene> has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine | [[Crixivan]], also known as Indinavir, is an antiviral compound that acts as a protease inhibitor. The <scene name='74/745991/Crixivan/2'>structure</scene> has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. The pyridine ring on Crixivan interacts with Arg8 in the protease to conform to the active site. The amide is attacked by the Asp25 of the protease, however the peptide bond doesn't lyse due to the stability of the molecule. | ||
== Function == | == Function == | ||