User:Kerry Frattarola/Sandbox 1: Difference between revisions

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==Human Immunodeficiency Virus protease inhibitor==

~~<applet load="" size="350" color="" frame="true" spin="on" Scene ="Indinavir/Indinavir/1" align="right" caption="Indinavir, better known as Crixivan, ([[1hsg]])"/>~~

==Structure==

Crixivan is an antiviral compound that acts as a protease inhibitor. Figure 2 below depicts Crixivan’s structure. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. Crixivan’s pyridine attracts protease Arg8 to hold it in place. Its ketone interacts with the protease Asp25 to perform initiate aspartic catalysis. The bond between the ketone and amine doesn't lyse due to the nature of the inhibitor.

[[Crixivan]] is an antiviral compound that acts as a protease inhibitor. Figure 2 below depicts Crixivan’s structure. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. Crixivan’s pyridine attracts protease Arg8 to hold it in place. Its ketone interacts with the protease Asp25 to perform initiate aspartic catalysis. The bond between the ketone and amine doesn't lyse due to the nature of the inhibitor.

== Function ==

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 ==Human Immunodeficiency Virus protease inhibitor==
-<applet   load="" size="350" color="" frame="true"  spin="on" Scene ="Indinavir/Indinavir/1" align="right" caption="Indinavir, better known as Crixivan, ([[1hsg]])"/>
 <StructureSection load='2b7z' size='340' side='right' caption='Structure of HIV-1 protease bound to indinavir, ([[2b7z]]), [[Resolution|resolution]] 2.20&Aring;' scene=''>
 ==Structure==
-Crixivan is an antiviral compound that acts as a protease inhibitor. Figure 2 below depicts Crixivan’s structure. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. Crixivan’s pyridine attracts protease Arg8 to hold it in place. Its ketone interacts with the protease Asp25 to perform initiate aspartic catalysis. The bond between the ketone and amine doesn't lyse due to the nature of the inhibitor.
+[[Crixivan]] is an antiviral compound that acts as a protease inhibitor. Figure 2 below depicts Crixivan’s structure. The drug has a molecular weight of 711.875 g/mol and is very soluble in water and ethanol <ref>Physicians Desk Reference 66th ed. PDR Network, LLC, Montvale, NJ. p. 2086 (2012)</ref>. Crixivan works by specifically binding to the HIV-1 protease active site by mimicking a target substrate protein and essentially becoming “stuck” in the enzyme active site, disabling the enzyme. Crixivan’s pyridine attracts protease Arg8 to hold it in place. Its ketone interacts with the protease Asp25 to perform initiate aspartic catalysis. The bond between the ketone and amine doesn't lyse due to the nature of the inhibitor.
 == Function ==