1pop: Difference between revisions

Revision as of 05:18, 3 May 2008

X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX

OverviewOverview

The three-dimensional structure of the papain-leupeptin complex has been determined by X-ray crystallography to a resolution of 2.1 A (overall R-factor = 19.8%). The structure indicates that: (i) leupeptin contacts the S subsites of the papain active site and not the S' subsites; (ii) the 'carbonyl' carbon atom of the inhibitor is covalently bound by the Cys-25 sulphur atom of papain and is tetrahedrally coordinated; (iii) the 'carbonyl' oxygen atom of the inhibitor faces the oxyanion hole and makes hydrogen bond contacts with Gln-19 and Cys-25.

About this StructureAbout this Structure

1POP is a Single protein structure. Full crystallographic information is available from OCA.

ReferenceReference

X-ray crystallographic structure of a papain-leupeptin complex., Schroder E, Phillips C, Garman E, Harlos K, Crawford C, FEBS Lett. 1993 Jan 2;315(1):38-42. PMID:8416808 Page seeded by OCA on Sat May 3 05:18:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1pop.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1pop |SIZE=350|CAPTION= <scene name='initialview01'>1pop</scene>, resolution 2.1&Aring;
+The line below this paragraph, containing "STRUCTURE_1pop", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1pop|  PDB=1pop  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pop OCA], [http://www.ebi.ac.uk/pdbsum/1pop PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pop RCSB]</span>
-}}
 '''X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX'''
@@ Line 19: / Line 16: @@
 ==About this Structure==
-POP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POP OCA].
+POP is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POP OCA].
 ==Reference==
@@ Line 27: / Line 24: @@
 [[Category: Crawford, C.]]
 [[Category: Schroder, E.]]
-[[Category: hydrolase(thiol protease)]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:18:55 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:02:26 2008''