5t47: Difference between revisions

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'''Unreleased structure'''


The entry 5t47 is ON HOLD until Paper Publication
==Crystal structure of the D. melanogaster eIF4E-eIF4G complex==
 
<StructureSection load='5t47' size='340' side='right' caption='[[5t47]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5t47]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T47 FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t47 OCA], [http://pdbe.org/5t47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t47 RCSB], [http://www.ebi.ac.uk/pdbsum/5t47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t47 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/IF4E_DROME IF4E_DROME]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.<ref>PMID:8663200</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chung, M Y]]
[[Category: Gruener, S]]
[[Category: Igreja, C]]
[[Category: Izaurralde, E]]
[[Category: Peter, D]]
[[Category: Valkov, E]]
[[Category: Weber, R]]
[[Category: Weichenrieder, O]]
[[Category: Wohlbold, L]]
[[Category: 4e-binding protein]]
[[Category: Cap binding protein]]
[[Category: Eif4f]]
[[Category: Gene regulation]]
[[Category: Translation]]
[[Category: Translation initiation]]

Revision as of 21:50, 26 October 2016

Crystal structure of the D. melanogaster eIF4E-eIF4G complexCrystal structure of the D. melanogaster eIF4E-eIF4G complex

Structural highlights

5t47 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[IF4E_DROME] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.[1]

References

  1. ↑ Lavoie CA, Lachance PE, Sonenberg N, Lasko P. Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins. J Biol Chem. 1996 Jul 5;271(27):16393-8. PMID:8663200

5t47, resolution 2.20Å

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OCA
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