Zbtb7: Difference between revisions
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==Introduction== | ==Introduction== | ||
Zbtb7 which was originally named as Pokemon (POK erythroid myeloid ontogenic factor) is a gene which plays a critical role in development, cellular differentiation and oncogenesis and has a crucial role in interacting with other POK family proteins.The gene was discovered in 2005 by the team of scientists from Memorial Sloan-Kettering Cancer Center, New York and Institute of Cancer Research, London. Scientists have reported the transcriptional repressor Pokemon as a critical factor in oncogenesis.[1] | Zbtb7 which was originally named as Pokemon (POK erythroid myeloid ontogenic factor) is a gene which plays a critical role in development, cellular differentiation and oncogenesis and has a crucial role in interacting with other POK family proteins.The gene was discovered in 2005 by the team of scientists from Memorial Sloan-Kettering Cancer Center, New York and Institute of Cancer Research, London. Scientists have reported the transcriptional repressor Pokemon as a critical factor in oncogenesis.[1] <Structure load='2NN2' size='350' frame='true' align='right' caption='BTB-zinc finger (BTB-ZF) proteins are transcription regulators with roles in development, differentiation, and oncogenesis. In these proteins, the BTB domain (also known as the POZ domain) is a protein-protein interaction motif that contains a dimerization interface, a possible oligomerization surface' scene='Insert optional scene name here' /> | ||
== Function == | == Function == | ||
Pokemon functions as a transcription regulator with active roles in cell growth, differentiation and oncogenesis. Pokemon interferes with GC box recognition by Sp1 via interacting with the zinc finger DNA binding domain, resulting in the repression of ADH5/FDH transcription. Pokemon also affects the transcription of nuclear factor (NF)-κB-responsive genes by associating with the p65 subunit and inducing its nuclear import and stabilization. The target genes of Pokemon include extracellular matrix collagen types I, II, IX, X and XI; aggrecan; fibronectin; elastin; cartilage oligomeric matrix protein (COMP); alcohol dehydrogenase ADH5/FDH, ARF and Rb tumor suppressors; and c-fos and c-myc oncoproteins [2] | Pokemon functions as a transcription regulator with active roles in cell growth, differentiation and oncogenesis. Pokemon interferes with GC box recognition by Sp1 via interacting with the zinc finger DNA binding domain, resulting in the repression of ADH5/FDH transcription. Pokemon also affects the transcription of nuclear factor (NF)-κB-responsive genes by associating with the p65 subunit and inducing its nuclear import and stabilization. The target genes of Pokemon include extracellular matrix collagen types I, II, IX, X and XI; aggrecan; fibronectin; elastin; cartilage oligomeric matrix protein (COMP); alcohol dehydrogenase ADH5/FDH, ARF and Rb tumor suppressors; and c-fos and c-myc oncoproteins [2] |