5swf: Difference between revisions

Revision as of 21:38, 10 December 2016

The structure of the PP2A B56 subunit double phosphorylated BubR1 complexThe structure of the PP2A B56 subunit double phosphorylated BubR1 complex

Structural highlights

5swf is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Related:	5sw9
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[2A5G_HUMAN] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.^[1] ^[2]

References

↑ Letourneux C, Rocher G, Porteu F. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. EMBO J. 2006 Feb 22;25(4):727-38. Epub 2006 Feb 2. PMID:16456541 doi:http://dx.doi.org/10.1038/sj.emboj.7600980
↑ Li HH, Cai X, Shouse GP, Piluso LG, Liu X. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO J. 2007 Jan 24;26(2):402-11. PMID:17245430 doi:http://dx.doi.org/10.1038/sj.emboj.7601519

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OCA

[1] Letourneux C, Rocher G, Porteu F. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. EMBO J. 2006 Feb 22;25(4):727-38. Epub 2006 Feb 2. PMID:16456541 doi:http://dx.doi.org/10.1038/sj.emboj.7600980

[2] Li HH, Cai X, Shouse GP, Piluso LG, Liu X. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO J. 2007 Jan 24;26(2):402-11. PMID:17245430 doi:http://dx.doi.org/10.1038/sj.emboj.7601519

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5swf is ON HOLD  until Paper Publication
+==The structure of the PP2A B56 subunit double phosphorylated BubR1 complex==
+<StructureSection load='5swf' size='340' side='right' caption='[[5swf]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
-Authors: Page, R., Wang, X., Bajaj, R., Peti, W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5swf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SWF FirstGlance]. <br>
-Description: The structure of the PP2A B56 subunit double phosphorylated BubR1 complex
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5sw9|5sw9]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5swf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5swf OCA], [http://pdbe.org/5swf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5swf RCSB], [http://www.ebi.ac.uk/pdbsum/5swf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5swf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/2A5G_HUMAN 2A5G_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.<ref>PMID:16456541</ref> <ref>PMID:17245430</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bajaj, R]]
 [[Category: Page, R]]
+[[Category: Peti, W]]
 [[Category: Wang, X]]
-[[Category: Bajaj, R]]
+[[Category: Cell cycle]]
-[[Category: Peti, W]]
+[[Category: Hydrolase]]
+[[Category: Phosphatase]]
+[[Category: Regulator]]
+[[Category: Slim]]

5swf: Difference between revisions

Revision as of 21:38, 10 December 2016

The structure of the PP2A B56 subunit double phosphorylated BubR1 complexThe structure of the PP2A B56 subunit double phosphorylated BubR1 complex

Structural highlights

Function

References

Contents

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5swf: Difference between revisions

Revision as of 21:38, 10 December 2016

The structure of the PP2A B56 subunit double phosphorylated BubR1 complexThe structure of the PP2A B56 subunit double phosphorylated BubR1 complex

Structural highlights

Function

References

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