5lv5: Difference between revisions

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-'''Unreleased structure'''
-The entry 5lv5 is ON HOLD  until Paper Publication
+==Crystal structure of mouse PRMT6 in complex with inhibitor LH1458==
+<StructureSection load='5lv5' size='340' side='right' caption='[[5lv5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Bonnefond, L., Cavarelli, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lv5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LV5 FirstGlance]. <br>
-Description: Crystal structure of mouse PRMT6 in complex with inhibitor LH1458
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=78G:2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]-[(3~{S})-3-azanyl-4-oxidanyl-4-oxidanylidene-butyl]azanium'>78G</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Prmt6, Hrmt1l6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_I_protein_arginine_methyltransferase Type I protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.319 2.1.1.319] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lv5 OCA], [http://pdbe.org/5lv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lv5 RCSB], [http://www.ebi.ac.uk/pdbsum/5lv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lv5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ANM6_MOUSE ANM6_MOUSE]] Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator.<ref>PMID:22904064</ref> <ref>PMID:24570487</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Lk3 transgenic mice]]
+[[Category: Type I protein arginine methyltransferase]]
+[[Category: Arimondo, P]]
+[[Category: Bonnefond, L]]
 [[Category: Cavarelli, J]]
-[[Category: Bonnefond, L]]
+[[Category: Cura, V]]
+[[Category: Halby, L]]
+[[Category: Marechal, N]]
+[[Category: Troffer-Charlier, N]]
+[[Category: S-adenosyl-l-methionine]]
+[[Category: Transferase]]