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Thiol:disulfide interchange protein: Difference between revisions

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<StructureSection load='1eej' size='350' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene='70/705687/Cv/1'>
<StructureSection load='1eej' size='340' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene=''>
== Function ==
== Function ==
'''Thiol:disulfide interchange protein''' (DsbC) is a prokaryotic disulfide bond isomerase.  <br />
'''Thiol:disulfide interchange protein''' (DsbC) is a prokaryotic disulfide bond isomerase.  <br />
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*'''DsbE''' catalyzes the reductive step in the assembly of periplasmic c-type cytochrome<ref>PMID:14597624</ref>.  <br />
*'''DsbE''' catalyzes the reductive step in the assembly of periplasmic c-type cytochrome<ref>PMID:14597624</ref>.  <br />
*'''DsbG''' provides reducing equivalents to rescue oxidatively-damaged secreted proteins<ref>PMID:9654144</ref>.
*'''DsbG''' provides reducing equivalents to rescue oxidatively-damaged secreted proteins<ref>PMID:9654144</ref>.
== Disease ==
== Relevance ==


== Structural highlights ==
== Structural highlights ==
DsbC active site contains a <scene name='70/705687/Cv/2'>CXXC motif</scene> which modulates the disulfide isomerization and protein folding in the bacterial periplasmic space<ref>PMID:11208797</ref>.
DsbC active site contains a CXXC motif which modulates the disulfide isomerization and protein folding in the bacterial periplasmic space<ref>PMID:11208797</ref>.
</StructureSection>
</StructureSection>


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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
*Thiol:disulfide interchange protein (DsbA) see [[Protein disulfide oxidoreductase]]


* Thiol:disulfide interchange protein (DsbC)
* Thiol:disulfide interchange protein (DsbC)
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**[[1jzd]] – EcDsbC (mutant) + DsbD N terminal<BR />
**[[1jzd]] – EcDsbC (mutant) + DsbD N terminal<BR />
**[[1t3b]] – DsbC – ''Haemophilus influenzae'' <BR />
**[[1t3b]] – DsbC – ''Haemophilus influenzae'' <BR />
**[[4fyb]], [[4fyc]] – DsbC – ''Helicobacter pylori'' <BR />
**[[4fyb]], [[4fyc]] – HpDsbC – ''Helicobacter pylori'' <BR />
**[[4i5q]] – StDsbC – ''Salmonella typhimurium''<BR />
**[[4i5q]] – StDsbC – ''Salmonella typhimurium''<BR />
**[[4ilf]] – StDsbC (mutant) <BR />
**[[4ilf]] – StDsbC (mutant) <BR />
**[[4np]] – DsbC –'' Yersinia pestis'' <BR /


*Thiol:disulfide interchange protein (DsbD)
*Thiol:disulfide interchange protein (DsbD)
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**[[1v57]], [[1v58]] – EcDsbG <BR />
**[[1v57]], [[1v58]] – EcDsbG <BR />
**[[2h0g]], [[2h0h]], [[2h0i]] – EcDsbG (mutant) <BR />
**[[2h0g]], [[2h0h]], [[2h0i]], [[5g1k]], [[5g1l] – EcDsbG (mutant) <BR />
**[[2iy2]] – EcDsbG N terminal<BR />
**[[2iy2]] – EcDsbG N terminal<BR />
**[[4ihu]] – MtDsbG  <BR />
**[[3tdg]] – HpDsbG<BR />
*Thiol:disulfide interchange protein (DsbP)
**[[4ml1]], [[4ml6]], [[4mly]] – DsbP – ''Klebsiella pneumoniae'' <BR />
}}
}}


== References ==
== References ==
<references/>
<references/>

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
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