Thioesterase: Difference between revisions
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* '''Ubiquitin TE''' or '''ubiquitin carboxyl-terminal hydrolase''' (USP) removes conjugated ubiquitin (UB) from proteins thus regulating protein level by preventing their degradation. USP hydrolyze the peptide bond at the C-terminal glycine of ubiquitin. The USPs are involved in the processing of poly-UB precursors and of ubiquitinated proteins<ref>PMID:24190967</ref>. USP contains catalytic domain surrounded several domains: Ub-like (UBL); Ub-associated (UBA); zinc finger-Ub-specific protease domain (UBP or DUSP); TRF homology domain. | * '''Ubiquitin TE''' or '''ubiquitin carboxyl-terminal hydrolase''' (USP) removes conjugated ubiquitin (UB) from proteins thus regulating protein level by preventing their degradation. USP hydrolyze the peptide bond at the C-terminal glycine of ubiquitin. The USPs are involved in the processing of poly-UB precursors and of ubiquitinated proteins<ref>PMID:24190967</ref>. USP contains catalytic domain surrounded several domains: Ub-like (UBL); Ub-associated (UBA); zinc finger-Ub-specific protease domain (UBP or DUSP); TRF homology domain. | ||
* USP-L1, USP25 hydrolyze C-terminal adducts of UB.<br /> | * '''USP-L1, USP25''' hydrolyze C-terminal adducts of UB.<br /> | ||
* USP-L3 | * '''USP-L3''' hydrolyzes C-terminal adducts of UB and NEDD8.<br /> | ||
* USP5 cleaves multiubiquitin polymers.<br /> | * '''USP5''' cleaves multiubiquitin polymers.<br /> | ||
* USP6 has ATP-independent isopeptidase activity.<br /> | * '''USP6''' has ATP-independent isopeptidase activity.<br /> | ||
* USP7, USP4, USP13, USP15 deubiquitinate several proteins.<br /> | * '''USP7, USP4, USP13, USP15''' deubiquitinate several proteins.<br /> | ||
* USP8 removes conjugated ubiquitin from proteins thus preventing protein degradation. USP8 is involved in cell proliferation and is active in the M phase of proliferation.<br /> | * USP8 removes conjugated ubiquitin from proteins thus preventing protein degradation. USP8 is involved in cell proliferation and is active in the M phase of proliferation.<br /> | ||
* USP11, USP14 are proteasome-associated.<br /> | * '''USP11, USP14''' are proteasome-associated.<br /> | ||
* USP12 stabilizes T-cell complexes<ref>PMID:26811477</ref>.<br /> | * '''USP12''' stabilizes T-cell complexes<ref>PMID:26811477</ref>.<br /> | ||
* USP16, USP21 deubiquitinate histone H2A.<br /> | * '''USP16, USP21''' deubiquitinate histone H2A.<br /> | ||
* USP18 is a down regulator of the type I interferon signaling pathway<ref>PMID:23700969</ref>.<br /> | * '''USP18''' is a down regulator of the type I interferon signaling pathway<ref>PMID:23700969</ref>.<br /> | ||
* USP28 deubiquitinates proteins of the DNA damage pathway.<br /> | * '''USP28''' deubiquitinates proteins of the DNA damage pathway.<br /> | ||
* USP33 regulates centrosome duplication.<br /> | * '''USP33''' regulates centrosome duplication.<br /> | ||
* USP37 deubiquitinates cyclin A.<br /> | * '''USP37''' deubiquitinates cyclin A.<br /> | ||
* USP46 deubiquitinates AMPA receptor<ref>PMID:26077708</ref>.<br /> | * '''USP46''' deubiquitinates AMPA receptor<ref>PMID:26077708</ref>.<br /> | ||
== Disease == | == Disease == | ||