5ln2: Difference between revisions
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==Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument== | ==Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument== | ||
<StructureSection load='5ln2' size='340' side='right' caption='[[5ln2]], [[Resolution|resolution]] 1.58Å' scene=''> | <StructureSection load='5ln2' size='340' side='right'caption='[[5ln2]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ln2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LN2 OCA]. For a <b>guided tour on the structure components</b> use [http:// | <table><tr><td colspan='2'>[[5ln2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LN2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LN2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ZT:(4~{S})-5-[5-CHLORANYL-2-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-4-(4-CHLORANYL-2-METHYL-PHENYL)-2-(2-METHOXYPHENYL)-3-PROPAN-2-YL-4~{H}-PYRROLO[3,4-C]PYRAZOL-6-ONE'>6ZT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6ZT:(4~{S})-5-[5-CHLORANYL-2-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-4-(4-CHLORANYL-2-METHYL-PHENYL)-2-(2-METHOXYPHENYL)-3-PROPAN-2-YL-4~{H}-PYRROLO[3,4-C]PYRAZOL-6-ONE'>6ZT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ln2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ln2 OCA], [http://pdbe.org/5ln2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ln2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ln2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ln2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5ln2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5ln2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[MDM2 3D structures|MDM2 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Kallen, J]] | [[Category: Kallen, J]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Inhibitor complex]] | [[Category: Inhibitor complex]] | ||
[[Category: Ppi with p53]] | [[Category: Ppi with p53]] | ||