1opg: Difference between revisions

Revision as of 04:07, 3 May 2008

OPG2 FAB FRAGMENT

OverviewOverview

Cell surface receptors called integrins mediate diverse cell adhesion phenomena through recognition of the sequence arginine-glycine-aspartic acid (RGD) present in proteins such as fibronectin and fibrinogen. Platelet aggregation in hemostasis is mediated by the binding of fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the heavy chain. The RYD loop and side chains are ordered in the 2.0-A resolution crystal structure of the Fab fragment from this antireceptor antibody. Moreover, the RYD loop assumes two clearly defined conformations that may correspond to the orientations of the loop in the free state or bound to integrin. This molecule will serve as a tool for understanding protein-integrin recognition in platelet aggregation and other RGD-mediated cell adhesion interactions.

About this StructureAbout this Structure

1OPG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site., Kodandapani R, Veerapandian B, Kunicki TJ, Ely KR, J Biol Chem. 1995 Feb 3;270(5):2268-73. PMID:7836460 Page seeded by OCA on Sat May 3 04:07:36 2008

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OCA

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 '''OPG2 FAB FRAGMENT'''
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 [[Category: Kodandapani, R.]]
 [[Category: Veerapandian, B.]]
-[[Category: cell adhesion molecule]]
+[[Category: Cell adhesion molecule]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:07:36 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:48:32 2008''