5l2t: Difference between revisions
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==The X-ray co-crystal structure of human CDK6 and Ribociclib.== | ==The X-ray co-crystal structure of human CDK6 and Ribociclib.== | ||
<StructureSection load='5l2t' size='340' side='right' caption='[[5l2t]], [[Resolution|resolution]] 2.37Å' scene=''> | <StructureSection load='5l2t' size='340' side='right'caption='[[5l2t]], [[Resolution|resolution]] 2.37Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5l2t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2T OCA]. For a <b>guided tour on the structure components</b> use [http:// | <table><tr><td colspan='2'>[[5l2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5L2T FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ZZ:7-CYCLOPENTYL-N,N-DIMETHYL-2-{[5-(PIPERAZIN-1-YL)PYRIDIN-2-YL]AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>6ZZ</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6ZZ:7-CYCLOPENTYL-N,N-DIMETHYL-2-{[5-(PIPERAZIN-1-YL)PYRIDIN-2-YL]AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE'>6ZZ</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5l2i|5l2i]], [[5l2s|5l2s]], [[5l2w|5l2w]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5l2i|5l2i]], [[5l2s|5l2s]], [[5l2w|5l2w]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK6, CDKN6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5l2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l2t OCA], [http://pdbe.org/5l2t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l2t RCSB], [http://www.ebi.ac.uk/pdbsum/5l2t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l2t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5l2t" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5l2t" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Cyclin-dependent kinase]] | [[Category: Cyclin-dependent kinase]] | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen, P]] | [[Category: Chen, P]] | ||
[[Category: Deihl, W]] | [[Category: Deihl, W]] |