5ls1: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ls1 is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR166475==
+<StructureSection load='5ls1' size='340' side='right' caption='[[5ls1]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors: VALLEE, F., DUPUY, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ls1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LS1 FirstGlance]. <br>
-Description: CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR166475
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=73Z:2-[(4-oxidanylidenecyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydroindol-1-yl)benzamide'>73Z</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-[[Category: Dupuy, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ls1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ls1 OCA], [http://pdbe.org/5ls1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ls1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ls1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ls1 ProSAT]</span></td></tr>
-[[Category: Vallee, F]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: DUPUY, A]]
+[[Category: VALLEE, F]]
+[[Category: Chaperone protein]]