1of5: Difference between revisions

Revision as of 03:46, 3 May 2008

CRYSTAL STRUCTURE OF MEX67-MTR2

OverviewOverview

The association between Mtr2 and Mex67 is essential for the nuclear export of bulk messenger RNA in yeast. In metazoans, the analogous function is carried out by the TAP-p15 heterodimer. Whereas Mex67 and TAP are highly conserved proteins, their binding partners, Mtr2 and p15, share no sequence similarity, but are nevertheless functionally homologous. Here, we report the 2.8-A resolution crystal structure of Mtr2 in complex with the NTF2-like domain of Mex67. Mtr2 is a novel member of the NTF2-like family and interacts with Mex67, forming a complex with a similar structural architecture to that of TAP-p15. Mtr2 fulfils an analogous function to that of human p15 in maintaining the structural integrity of the heterodimer. In addition, Mtr2 presents a long internal loop, which contains residues that affect the export of the large ribosomal subunit.

About this StructureAbout this Structure

1OF5 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15., Fribourg S, Conti E, EMBO Rep. 2003 Jul;4(7):699-703. PMID:12835756 Page seeded by OCA on Sat May 3 03:46:02 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1of5.gif|left|200px]]
- {{Structure
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 '''CRYSTAL STRUCTURE OF MEX67-MTR2'''
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 [[Category: Conti, E.]]
 [[Category: Fribourg, S.]]
-[[Category: leucine-rich repeat]]
+[[Category: Leucine-rich repeat]]
-[[Category: mrna transport]]
+[[Category: Mrna transport]]
-[[Category: nuclear protein]]
+[[Category: Nuclear protein]]
-[[Category: nuclear transport]]
+[[Category: Nuclear transport]]
-[[Category: repeat]]
+[[Category: Repeat]]
-[[Category: transport]]
+[[Category: Transport]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:46:02 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:44:23 2008''