Phosphocarrier protein: Difference between revisions
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== Function == | == Function == | ||
'''Phosphocarrier protein HPr''' (HPr) is a component of the sugar phosphotransferase system. The system catalyses the phosphorylation of sugars during their translocation across cell membrane. A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr<ref>PMID:8246840</ref>. A conserved histidine in the N terminal of HPr is the acceptor of the phosphate. In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated. | '''Phosphocarrier protein HPr''' (HPr) is a component of the sugar phosphotransferase system. The system catalyses the phosphorylation of sugars during their translocation across cell membrane. A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr<ref>PMID:8246840</ref>. A conserved histidine in the N terminal of HPr is the acceptor of the phosphate. In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated. | ||
'''Phosphocarrier protein NPr''' (NPr) is a component of the sugar phosphotransferase system. NPr is a phosphoryl transfer protein, homologous to HPr which functions to regulate nitrogen metabolism<ref>PMID:18421563</ref>. | |||
'''Phosphocarrier protein III Glc''' (PcpIII) is a signal-transducing component of the phosphoenolpyruvate:glycose phosphotransferase system of ''E. coli''<ref>PMID:11168402</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
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**[[1ggr]], [[1j6t]], [[1vrc]] - EcHPr + EII N terminal + PO3 – NMR <br /> | **[[1ggr]], [[1j6t]], [[1vrc]] - EcHPr + EII N terminal + PO3 – NMR <br /> | ||
**[[2lrk]], [[2lrl]] - EcHPr + EII N terminal – NMR <br /> | **[[2lrk]], [[2lrl]] - EcHPr + EII N terminal – NMR <br /> | ||
**[[4xwj]] - EcHPr + antisigma factor RSD <br /> | |||
**[[1kkl]] - BsHPr (mutant) + HPrK <br /> | **[[1kkl]] - BsHPr (mutant) + HPrK <br /> | ||
**[[1kkm]] - BsHPr (mutant) with phosphoserine + HPrK/P <br /> | **[[1kkm]] - BsHPr (mutant) with phosphoserine + HPrK/P <br /> | ||
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**[[2nzv]] - BmHPr with phosphoserine + BmCcpA + fructose-1,6-diphosphate <br /> | **[[2nzv]] - BmHPr with phosphoserine + BmCcpA + fructose-1,6-diphosphate <br /> | ||
**[[3oqm]], [[3oqn]], [[3oqo]] - BsHPr with phosphoserine + BsCcpA + DNA<br /> | **[[3oqm]], [[3oqn]], [[3oqo]] - BsHPr with phosphoserine + BsCcpA + DNA<br /> | ||
*Phosphocarrier protein NPr | |||
**[[5t17]], [[5t1n]] - EcNPr – NMR <br /> | |||
**[[5t1o]] - EcNPr + EIN-NTR – NMR <br /> | |||
*Phosphocarrier protein III Glc | |||
**[[1f3g]] - EcPrcpIII <br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||