Stimulator of interferon genes: Difference between revisions
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<StructureSection load=' | <StructureSection load='4loh' size='350' side='right' caption='Structure of human STING CTD complex with c-GMP-AMP (stick model) (PDB entry [[4loh]])' scene=''> | ||
'''Stimulator of interferon genes''' (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling<ref>PMID:26980676</ref>. | '''Stimulator of interferon genes''' (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling<ref>PMID:26980676</ref>. | ||
== Structural highlights == | |||
The cyclic dinucleotide binds the STING in a U-shaped cleft between the 2 monomers<ref>PMID:23910378</ref>. | |||
</StructureSection> | </StructureSection> | ||