Serpin: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load='2xn6' size='350' side='right' caption='Structure of cleaved human serpin A7. Residues 32-380 (grey), residues 381-415 (green) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene=''> | |||
<StructureSection load='2xn6' size='350' side='right' caption='Structure of cleaved human serpin A7. Residues 32-380 (grey), residues 381-415 (green) complex with thyroxine-fluoresein (PDB entry [[2xn6]])' scene=''> | |||
== Function == | == Function == | ||
'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br /> | '''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br /> | ||
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== Disease == | == Disease == | ||
Mutation in Ser A7 causes partial thyroxine-binding globulin deficiency<ref>PMID:24356794</ref>. Ser B3 may contribute to tumor cell resistance to anti-neoplastic drugs<ref>PMID:25332258</ref>. Ser A3 promotes growth of endometrial cancer cells <ref>PMID:24817931</ref>. | Mutation in Ser A7 causes partial thyroxine-binding globulin deficiency<ref>PMID:24356794</ref>. Ser B3 may contribute to tumor cell resistance to anti-neoplastic drugs<ref>PMID:25332258</ref>. Ser A3 promotes growth of endometrial cancer cells <ref>PMID:24817931</ref>. | ||
==Structural highlights == | |||
Ser A7 - a thyrosine-binding globulin - binding site contains thyroxin derivative<ref>PMID:21325280</ref>. | |||
</StructureSection> | </StructureSection> | ||