1nz0: Difference between revisions

Revision as of 03:09, 3 May 2008

RNASE P PROTEIN FROM THERMOTOGA MARITIMA

OverviewOverview

The structure of RNase P protein from the hyperthermophilic bacterium Thermotoga maritima was determined at 1.2-A resolution by using x-ray crystallography. This protein structure is from an ancestral-type RNase P and bears remarkable similarity to the recently determined structures of RNase P proteins from bacteria that have the distinct, Bacillus type of RNase P. These two types of protein span the extent of bacterial RNase P diversity, so the results generalize the structure of the bacterial RNase P protein. The broad phylogenetic conservation of structure and distribution of potential RNA-binding elements in the RNase P proteins indicate that all of these homologous proteins bind to their cognate RNAs primarily by interaction with the phylogenetically conserved core of the RNA. The protein is found to dimerize through an extensive, well-ordered interface. This dimerization may reflect a mechanism of thermal stability of the protein before assembly with the RNA moiety of the holoenzyme.

About this StructureAbout this Structure

1NZ0 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

ReferenceReference

High-resolution structure of RNase P protein from Thermotoga maritima., Kazantsev AV, Krivenko AA, Harrington DJ, Carter RJ, Holbrook SR, Adams PD, Pace NR, Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7497-502. Epub 2003 Jun 10. PMID:12799461 Page seeded by OCA on Sat May 3 03:09:25 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1nz0.gif|left|200px]]
- {{Structure
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-|GENE= RNPA OR TM1463 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nz0 OCA], [http://www.ebi.ac.uk/pdbsum/1nz0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nz0 RCSB]</span>
-}}
 '''RNASE P PROTEIN FROM THERMOTOGA MARITIMA'''
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 [[Category: Krivenko, A A.]]
 [[Category: Pace, N R.]]
-[[Category: alfa-beta sandwich]]
+[[Category: Alfa-beta sandwich]]
-[[Category: berkeley structural genomics center]]
+[[Category: Berkeley structural genomics center]]
-[[Category: bsgc structure funded by nih]]
+[[Category: Bsgc structure funded by nih]]
-[[Category: dimer]]
+[[Category: Dimer]]
-[[Category: endonuclease]]
+[[Category: Endonuclease]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi]]
+[[Category: Psi]]
-[[Category: rnase]]
+[[Category: Rnase]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:09:25 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:37:31 2008''