4exm: Difference between revisions

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 ==The crystal structure of an engineered phage lysin containing the binding domain of pesticin and the killing domain of T4-lysozyme==
-<StructureSection load='4exm' size='340' side='right' caption='[[4exm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='4exm' size='340' side='right'caption='[[4exm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4exm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EXM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4exm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EXM FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4epi|4epi]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4exm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4exm OCA], [https://pdbe.org/4exm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4exm RCSB], [https://www.ebi.ac.uk/pdbsum/4exm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4exm ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pst, YP_pPCP06, YPPCP1.05c, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4exm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4exm OCA], [http://pdbe.org/4exm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4exm RCSB], [http://www.ebi.ac.uk/pdbsum/4exm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4exm ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/Q57159_YERPE Q57159_YERPE]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Lysozyme]]
+[[Category: Escherichia virus T4]]
-[[Category: Barnard, T J]]
+[[Category: Large Structures]]
-[[Category: Buchanan, S K]]
+[[Category: Yersinia pestis]]
-[[Category: Fairman, J W]]
+[[Category: Barnard TJ]]
-[[Category: Lukacik, P]]
+[[Category: Buchanan SK]]
-[[Category: Noinaj, N]]
+[[Category: Fairman JW]]
-[[Category: Seddiki, N]]
+[[Category: Lukacik P]]
-[[Category: Bacterial lysin]]
+[[Category: Noinaj N]]
-[[Category: Hydrolase]]
+[[Category: Seddiki N]]
-[[Category: Toxin]]