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==Crystal structure of BT_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loop==
==Crystal structure of BT_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loop==
<StructureSection load='4jb3' size='340' side='right' caption='[[4jb3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4jb3' size='340' side='right'caption='[[4jb3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jb3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JB3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JB3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jb3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JB3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BT_0970 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226186 BACTN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jb3 OCA], [https://pdbe.org/4jb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jb3 RCSB], [https://www.ebi.ac.uk/pdbsum/4jb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jb3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jb3 OCA], [http://pdbe.org/4jb3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jb3 RCSB], [http://www.ebi.ac.uk/pdbsum/4jb3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jb3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RIBX_BACTN RIBX_BACTN] Catalyzes the dephosphorylation of D-ribitol-5-phosphate and D-ribitol-1-phosphate. Is also able to dephosphorylate 5-amino-6-(5-phospho-D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway.<ref>PMID:25513739</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bactn]]
[[Category: Bacteroides thetaiotaomicron VPI-5482]]
[[Category: Allen, K N]]
[[Category: Large Structures]]
[[Category: Almo, S C]]
[[Category: Al Obaidi NF]]
[[Category: Bhosle, R]]
[[Category: Allen KN]]
[[Category: Chowdhury, S]]
[[Category: Almo SC]]
[[Category: Dunaway-Mariano, D]]
[[Category: Bhosle R]]
[[Category: EFI, Enzyme Function Initiative]]
[[Category: Chowdhury S]]
[[Category: Evans, B]]
[[Category: Dunaway-Mariano D]]
[[Category: Gerlt, J A]]
[[Category: Evans B]]
[[Category: Ghosh, A]]
[[Category: Gerlt JA]]
[[Category: Glenn, A Scott]]
[[Category: Ghosh A]]
[[Category: Hammonds, J]]
[[Category: Hammonds J]]
[[Category: Hillerich, B]]
[[Category: Hillerich B]]
[[Category: Imker, H J]]
[[Category: Imker HJ]]
[[Category: Kumar, P R]]
[[Category: Kumar PR]]
[[Category: Love, J]]
[[Category: Love J]]
[[Category: Obaidi, N F.Al]]
[[Category: Scott Glenn A]]
[[Category: Seidel, R D]]
[[Category: Seidel RD]]
[[Category: Stead, M]]
[[Category: Stead M]]
[[Category: Toro, R]]
[[Category: Toro R]]
[[Category: Vetting, M W]]
[[Category: Vetting MW]]
[[Category: Washington, E]]
[[Category: Washington E]]
[[Category: Efi]]
[[Category: Enzyme function initiative]]
[[Category: Had]]
[[Category: Hydrolase]]
[[Category: Structural genomic]]

Revision as of 14:03, 24 November 2022

Crystal structure of BT_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loopCrystal structure of BT_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loop

Structural highlights

4jb3 is a 1 chain structure with sequence from Bacteroides thetaiotaomicron VPI-5482. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RIBX_BACTN Catalyzes the dephosphorylation of D-ribitol-5-phosphate and D-ribitol-1-phosphate. Is also able to dephosphorylate 5-amino-6-(5-phospho-D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway.[1]

References

  1. ↑ London N, Farelli JD, Brown SD, Liu C, Huang H, Korczynska M, Al-Obaidi NF, Babbitt PC, Almo SC, Allen KN, Shoichet BK. Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases. Biochemistry. 2015 Jan 20;54(2):528-37. doi: 10.1021/bi501140k. Epub 2015 Jan 5. PMID:25513739 doi:http://dx.doi.org/10.1021/bi501140k

4jb3, resolution 1.50Å

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OCA
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