1muj: Difference between revisions
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'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide''' | '''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide''' | ||
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[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
[[Category: Zhu, Y.]] | [[Category: Zhu, Y.]] | ||
[[Category: | [[Category: Antigen]] | ||
[[Category: | [[Category: Clip]] | ||
[[Category: | [[Category: Complex]] | ||
[[Category: | [[Category: Crystal structure]] | ||
[[Category: | [[Category: I-ab]] | ||
[[Category: | [[Category: Peptide]] | ||
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Revision as of 01:44, 3 May 2008
Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide
OverviewOverview
Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.
About this StructureAbout this Structure
1MUJ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:12589760 Page seeded by OCA on Sat May 3 01:44:17 2008