1mr3: Difference between revisions

Revision as of 01:37, 3 May 2008

Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution

OverviewOverview

Structures were determined by x-ray crystallography for two members of the ADP-ribosylation factor (ARF) family of regulatory GTPases, yeast ARF1 and ARL1, and were compared with previously determined structures of human ARF1 and ARF6. These analyses revealed an overall conserved fold but differences in primary sequence and length, particularly in an N-terminal loop, lead to differences in nucleotide and divalent metal binding. Packing of hydrophobic residues is central to the interplay between the N-terminal alpha-helix, switch I, and the interswitch region, which along with differences in surface electrostatics provide explanations for the different biophysical and biochemical properties of ARF and ARF-like proteins.

About this StructureAbout this Structure

1MR3 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:11535602 Page seeded by OCA on Sat May 3 01:37:16 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1mr3.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1mr3 |SIZE=350|CAPTION= <scene name='initialview01'>1mr3</scene>, resolution 1.60&Aring;
+The line below this paragraph, containing "STRUCTURE_1mr3", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=G3D:GUANOSINE-3&#39;-MONOPHOSPHATE-5&#39;-DIPHOSPHATE'>G3D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= ARF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
+-->
-|DOMAIN=
+{{STRUCTURE_1mr3|  PDB=1mr3  |  SCENE=  }}
-|RELATEDENTRY=[[1hur|1hur]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr3 OCA], [http://www.ebi.ac.uk/pdbsum/1mr3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mr3 RCSB]</span>
-}}
 '''Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution'''
@@ Line 33: / Line 30: @@
 [[Category: Wang, Y.]]
 [[Category: Zhu, X.]]
-[[Category: gdp-3'phosphate]]
+[[Category: Gdp-3'phosphate]]
-[[Category: gtp-binding]]
+[[Category: Gtp-binding]]
-[[Category: signal transduction]]
+[[Category: Signal transduction]]
-[[Category: small gtpase]]
+[[Category: Small gtpase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:37:16 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:19:58 2008''