3cvk: Difference between revisions
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==Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor== | ==Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor== | ||
<StructureSection load='3cvk' size='340' side='right' caption='[[3cvk]], [[Resolution|resolution]] 2.31Å' scene=''> | <StructureSection load='3cvk' size='340' side='right'caption='[[3cvk]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3cvk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVK OCA]. For a <b>guided tour on the structure components</b> use [http:// | <table><tr><td colspan='2'>[[3cvk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CVK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CVK FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N34:N-{3-[1-(3,3-DIMETHYL-BUTYL)-4-HYDROXY-2-OXO-1,2,4A,5,6,7-HEXAHYDRO-PYRROLO[1,2-B]PYRIDAZIN-3-YL]-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[1,2,4]THIADIAZIN-7-YL}-METHANESULFONAMIDE'>N34</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N34:N-{3-[1-(3,3-DIMETHYL-BUTYL)-4-HYDROXY-2-OXO-1,2,4A,5,6,7-HEXAHYDRO-PYRROLO[1,2-B]PYRIDAZIN-3-YL]-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[1,2,4]THIADIAZIN-7-YL}-METHANESULFONAMIDE'>N34</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3co9|3co9]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3co9|3co9]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3cvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cvk OCA], [http://pdbe.org/3cvk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cvk RCSB], [http://www.ebi.ac.uk/pdbsum/3cvk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cvk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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==See Also== | ==See Also== | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Hcv]] | [[Category: Hcv]] | ||
[[Category: Large Structures]] | |||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Han, Q]] | [[Category: Han, Q]] | ||