4j26: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Estrogen Receptor in complex with proline-flanked LXXLL peptides== | ==Estrogen Receptor in complex with proline-flanked LXXLL peptides== | ||
<StructureSection load='4j26' size='340' side='right' caption='[[4j26]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4j26' size='340' side='right'caption='[[4j26]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4j26]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4j26]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J26 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j26 OCA], [https://pdbe.org/4j26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j26 RCSB], [https://www.ebi.ac.uk/pdbsum/4j26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j26 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 20: | ||
==See Also== | ==See Also== | ||
*[[Estrogen receptor|Estrogen receptor]] | *[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Agten | [[Category: Large Structures]] | ||
[[Category: Brunsveld | [[Category: Agten S]] | ||
[[Category: Burton | [[Category: Brunsveld L]] | ||
[[Category: Fuchs | [[Category: Burton M]] | ||
[[Category: Goodarzifard | [[Category: Fuchs S]] | ||
[[Category: Goodarzifard M]] | |||
[[Category: Milroy | [[Category: Milroy LG]] | ||
[[Category: Nguyen | [[Category: Nguyen HD]] | ||
[[Category: Nieto | [[Category: Nieto L]] | ||
[[Category: Ottmann | [[Category: Ottmann C]] | ||
[[Category: Phan | [[Category: Phan T]] | ||
[[Category: Rose | [[Category: Rose R]] | ||
[[Category: Schmidt | [[Category: Schmidt A]] | ||
[[Category: | [[Category: De Vries-van Leeuwen I]] | ||